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Related Concept Videos

Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Related Experiment Video

Updated: Dec 14, 2025

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
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Optical coherence tomography for retinal imaging in multiple sclerosis.

Hanna Zimmermann1, Timm Oberwahrenbrock1, Alexander U Brandt1

  • 1NeuroCure Clinical Research Center.

Degenerative Neurological and Neuromuscular Disease
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) quantifies retinal nerve fiber layer (RNFL) thinning in multiple sclerosis (MS). OCT detects damage even without optic neuritis and aids in differential diagnosis, complementing brain imaging for neurodegeneration assessment.

Keywords:
Susac syndromemultiple sclerosisneuromyelitis opticaoptic neuritisretinal nerve fiber layervisual function

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Area of Science:

  • Neuro-ophthalmology
  • Neuroimaging
  • Multiple Sclerosis Research

Background:

  • Inflammatory and demyelinating diseases, particularly multiple sclerosis (MS), frequently cause visual disturbances due to optic nerve involvement.
  • Optical coherence tomography (OCT) is an advanced imaging technique increasingly utilized for assessing retinal damage in neurological conditions.
  • The retinal nerve fiber layer (RNFL) is a crucial component of the optic nerve and central nervous system, making its structure measurable via OCT.

Purpose of the Study:

  • To highlight the utility of OCT in quantifying retinal damage in MS patients.
  • To explore OCT's role in detecting both clinical and subclinical RNFL thinning in MS.
  • To evaluate OCT's potential in differentiating MS from other neurological disorders and its correlation with brain atrophy.

Main Methods:

  • Utilizing spectral interferometry with low-coherent infrared light to obtain high-resolution retinal images.
  • Performing noninvasive, micrometer-resolution measurements of RNFL thickness.
  • Correlating OCT findings with magnetic resonance imaging (MRI) data of brain structures.

Main Results:

  • Demonstrated distinct RNFL thinning in MS patients following acute optic neuritis.
  • Identified subclinical RNFL thinning in MS patients with no prior optic neuritis history.
  • Showcased OCT's ability to differentiate MS from neuromyelitis optica and Susac syndrome based on distinct thinning patterns.
  • Established associations between RNFL thinning and brain atrophy metrics (whole-brain, gray/white matter, optic radiation).

Conclusions:

  • OCT is a valuable, noninvasive tool for measuring RNFL thickness and detecting neurodegeneration in MS.
  • OCT findings correlate with brain atrophy, suggesting its utility as a complementary biomarker for CNS neurodegeneration.
  • OCT aids in differential diagnosis of MS and holds promise for monitoring neuroprotective therapies in clinical trials.