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Updated: Dec 14, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Association between Prediabetes and Renal Dysfunction from a Community-based Prospective Study.

Chao Chen1, Guangxu Liu2, Xiaolan Yu3

  • 1Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

International Journal of Medical Sciences
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Prediabetes increases the risk of renal dysfunction. Postprandial plasma glucose (PPG) shows a higher risk and predictive value for kidney disease compared to fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c).

Keywords:
associationprediabetesrenal dysfunction

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Area of Science:

  • Endocrinology
  • Nephrology
  • Public Health

Background:

  • Prediabetes is a growing public health concern.
  • Renal dysfunction, a serious complication, is often linked to glucose metabolism disorders.
  • Identifying specific glycemic markers associated with renal dysfunction is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between prediabetes and renal dysfunction.
  • To compare the risk of renal dysfunction posed by different glycemic indices: fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and hemoglobin A1c (HbA1c).

Main Methods:

  • A community-based prospective cohort study involving 7015 participants.
  • Renal dysfunction defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m².
  • Logistic regression and Receiver Operating Curve (ROC) analyses were employed to assess associations and predictive values.

Main Results:

  • 121 cases of renal dysfunction were identified.
  • Prediabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and elevated HbA1c were all associated with increased odds of renal dysfunction.
  • Impaired glucose tolerance (IGT) showed a higher risk, and PPG demonstrated a greater predictive value for renal dysfunction compared to FPG and HbA1c.

Conclusions:

  • Prediabetes is significantly associated with an elevated risk of developing renal dysfunction.
  • Postprandial plasma glucose (PPG) is a stronger predictor of renal dysfunction risk and has higher predictive value than FPG and HbA1c.