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Published on: December 28, 2010
The After-Effect of Accelerated Intermittent Theta Burst Stimulation at Different Session Intervals
Fengyun Yu1,2, Xinwei Tang1, Ruiping Hu1
1Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Objective:
The study aims to investigate the after-effect of three sessions of intermittent theta-burst stimulation (iTBS) on motor cortical excitability. The iTBS was induced over the primary motor cortex (M1) at different time intervals.
Methods:
The study has a crossover design. Sixteen participants were assigned to three groups and received different accelerated iTBS (aiTBS) protocols during each visit: (1) three continuous sessions with no interval (iTBS18000); (2) three iTBS sessions with 10-min intervals (iTBS600 × 3∗10); and (3) three iTBS sessions with 30-min intervals (iTBS600 × 3∗30). As washout period, each visit is separated by at least 7 days. We measured the motor cortical excitability changes and intracortical inhibition.
Results:
A dose of 1,800 pulses of aiTBS per day is tolerable. The iTBS1800 led to a reduced cortical excitability; whereas iTBS600 × 3∗10 and iTBS600 × 3∗30 enhanced cortical excitability to a differential extent. After a total dose of 1,800 pulses, iTBS600 × 3∗30 exhibited the longer effect and highest percentage of individuals with enhanced cortical excitability.
Conclusion:
The results suggest that aiTBS protocols at different time intervals result in different motor cortical excitability after-effects.
