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Related Experiment Videos

B cell dependent T lymphocyte responses in leishmaniasis.

D L Sacks1

  • 1Laboratory of Parasitic Diseases, NIAID, Bethesda, MD 20892.

Memorias Do Instituto Oswaldo Cruz
|November 1, 1988
PubMed
Summary

B cell dependent T cells are crucial for controlling Leishmania infection in mice. Their presence in humans with asymptomatic infections suggests a role in immunity, but their function in active disease remains unclear.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Parasitology

Background:

  • T cells play a critical role in the immune response to Leishmania infection.
  • B cell dependent T cells, specifically idiotype-recognizing T cells, have been observed in Leishmania-sensitized individuals.

Purpose of the Study:

  • To investigate the role of B cell dependent, idiotype-specific T cells in Leishmania infection.
  • To determine if these T cells are involved in protective immunity or unresponsiveness.

Main Methods:

  • Studies in genetically susceptible and resistant mouse strains.
  • Analysis of T cell populations in human populations with varying Leishmania exposure and disease status.

Main Results:

  • The removal of B cell dependent T cells significantly impacts Leishmania infection outcomes in mice.
  • Idiotype-recognizing T cells are present in humans with asymptomatic or subclinical Leishmania infections.
  • These T cells are absent in patients with active visceral leishmaniasis.

Conclusions:

  • B cell dependent, idiotype-specific T cells are important in the immune response to Leishmania.
  • These cells may play a role in immunity in humans with asymptomatic infections.
  • Their function in promoting specific unresponsiveness requires further investigation, especially in the context of active disease.

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