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Myocardial Perfusion Imaging Using Positron Emission Tomography

K Carlos El-Tallawi1, Ahmed Aljizeeri2, Faisal Nabi1

  • 1HOUSTON METHODIST DEBAKEY HEART & VASCULAR CENTER, HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Methodist Debakey Cardiovascular Journal
|July 17, 2020
PubMed

Insights

Positron emission tomography (PET) offers accurate noninvasive diagnosis of coronary artery disease (CAD). PET imaging of myocardial blood flow (MBF) and coronary flow reserve (CFR) provides crucial prognostic data for patients.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Coronary artery disease (CAD) is a leading cause of death globally.
  • Early diagnosis of CAD is crucial for patient outcomes.
  • Noninvasive diagnostic tools are essential for managing CAD burden.

Purpose of the Study:

  • To review the technical aspects and clinical utility of Positron Emission Tomography (PET) in diagnosing coronary artery disease.
  • To highlight PET's role in evaluating both epicardial and microcirculatory coronary disease.
  • To compare PET with other imaging modalities for myocardial perfusion imaging.

Main Methods:

  • Utilizing Positron Emission Tomography (PET) for myocardial perfusion imaging (MPI).
  • Measuring rest and stress myocardial blood flow (MBF) and coronary flow reserve (CFR).
  • Reviewing US Food and Drug Administration-approved radiotracers for PET imaging.

Main Results:

  • PET provides accurate relative myocardial perfusion imaging (MPI).
  • MBF and CFR measurements offer valuable insights into coronary microvasculature function.
  • Evidence supports the diagnostic and prognostic value of MBF and CFR in diverse patient groups.

Conclusions:

  • PET is a versatile tool for the noninvasive diagnosis and prognosis of CAD.
  • Evaluation of coronary microcirculation using PET-derived MBF and CFR is clinically significant.
  • PET imaging aids in assessing both epicardial and microcirculatory components of coronary artery disease.

Keywords:
coronary flow reserveendothelial dysfunctionmyocardial blood flowpositron emission tomography

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