RNA interference in glial cells for nerve injury treatment
Junquan Lin1, Seung Bin Jo2, Tae-Hyun Kim2,3
1School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
Journal of Tissue Engineering
|July 17, 2020
Abstract:
Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.
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