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Localized Breast Amyloidosis Associated with Sjörgren Syndrome.

Edgar G Fischer¹

¹Division of Surgical Pathology and Cytopathology, Department of Pathology MSC08 4640, University of New Mexico, Albuquerque, NM 87131, USA.

Case Reports in Pathology

|July 17, 2020

Summary

Sjörgren syndrome rarely involves amyloid deposits. This case highlights a rare association of Sjörgren syndrome with localized breast amyloidosis, emphasizing the need for broader diagnostic considerations.

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Area of Science:

Rheumatology
Pathology
Oncology

Background:

Sjörgren syndrome is a systemic autoimmune disorder.
Amyloidosis, characterized by abnormal protein deposits, can affect various organs.
Breast amyloidosis is an exceptionally rare manifestation.

Observation:

A 61-year-old female with Sjörgren syndrome presented with breast calcifications.
A biopsy revealed amyloid deposits in breast tissue, including periductular membranes and vasculature.
No malignancy or systemic amyloidosis was detected.

Findings:

This case represents one of the few documented instances of Sjörgren syndrome associated with breast amyloidosis.
The amyloid deposits were localized exclusively to the breast.
No underlying hematolymphoid neoplasm was identified.

Implications:

The rare association between Sjörgren syndrome and breast amyloidosis may be an emerging clinical finding.
Localized amyloid deposits in the breast warrant investigation for autoimmune conditions like Sjörgren syndrome.
This underscores the importance of considering autoimmune etiologies in unexplained localized amyloidosis.