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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
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Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Related Experiment Video

Updated: Dec 14, 2025

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
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Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

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Autophagy and Leukemia.

Zhong Zheng1, Li Wang1, Shu Cheng1

  • 1State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Advances in Experimental Medicine and Biology
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Leukemia, a cancer of blood stem cells, is increasingly studied for new treatments. Autophagy, a cell death process, impacts leukemia's immune response, stem cell differentiation, and drug resistance, offering potential therapeutic targets.

Keywords:
Acute myeloid leukemiaAutophagyChronic myeloid leukemiaMyelodysplastic syndrome

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Area of Science:

  • Hematology
  • Cancer Biology
  • Cellular Biology

Background:

  • Leukemia is a malignant clonal disease originating from hematopoietic stem cells.
  • Leukemia treatment has advanced from cytotoxic drugs to therapies inducing differentiation and apoptosis.
  • Autophagy is emerging as a significant form of cell death with implications in cancer.

Purpose of the Study:

  • To explore the role of autophagy in leukemia.
  • To investigate how autophagy influences key aspects of leukemia biology and treatment response.
  • To identify autophagy regulation as a potential targeted therapy strategy.

Main Methods:

  • Review of molecular biology and immunology research in the hematopoietic system.
  • Analysis of the impact of autophagy on immune response.
  • Examination of autophagy's effect on hematopoietic stem cell differentiation.
  • Assessment of autophagy's role in tumor cell drug resistance.

Main Results:

  • Autophagy influences the immune response in leukemia.
  • Autophagy affects hematopoietic stem cell differentiation.
  • Autophagy plays a role in the drug resistance of leukemia cells.

Conclusions:

  • Autophagy is a critical cellular process implicated in leukemia.
  • Modulating autophagy presents a promising avenue for targeted leukemia therapy.
  • Further research into autophagy regulation could lead to novel treatment strategies.