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Related Concept Videos

Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Autophagy01:27

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Updated: Dec 14, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

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Autophagy and Lymphoma.

Zhong Zheng1, Li Wang1, Shu Cheng1

  • 1State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Advances in Experimental Medicine and Biology
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Autophagy regulation offers a novel therapeutic strategy for lymphoma, a growing hematological malignancy. Targeting autophagy may overcome chemotherapy resistance and improve patient outcomes in B-cell lymphoma.

Keywords:
AKT/mTOR pathwayAMPK pathwayAutophagyLymphoma

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Area of Science:

  • Oncology
  • Hematology
  • Cell Biology

Background:

  • Lymphoma incidence is increasing globally.
  • CD20 monoclonal antibody therapy enhances treatment for CD20-positive B-cell lymphoma.
  • Chemotherapy resistance and relapse remain significant challenges in lymphoma treatment.

Purpose of the Study:

  • To explore the role of autophagy in lymphoma.
  • To investigate autophagy as a potential therapeutic target for improving lymphoma treatment outcomes.
  • To identify new strategies for overcoming treatment resistance in lymphoma.

Main Methods:

  • Review of current literature on lymphoma pathogenesis and treatment.
  • Analysis of the dual role of autophagy in cancer, particularly in protecting tumor cells.
  • Exploration of therapeutic interventions targeting autophagy pathways.

Main Results:

  • Autophagy acts as a survival mechanism for tumor cells under stress (hypoxia, radiotherapy, apoptosis).
  • Dysregulation of autophagy is implicated in chemotherapy resistance and disease relapse in lymphoma.
  • Targeting autophagy presents a promising avenue for novel lymphoma therapies.

Conclusions:

  • Active regulation of autophagy could represent a new approach to improve lymphoma treatment.
  • Modulating autophagy may enhance the efficacy of existing therapies and overcome resistance.
  • Further research into autophagy modulation is crucial for developing improved lymphoma treatments.