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Related Experiment Video

Updated: Dec 14, 2025

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CIMT as a risk factor for stroke subtype: A systematic review.

Pradeep Kumar1, Rakhee Sharma2, Shubham Misra1

  • 1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

European Journal of Clinical Investigation
|July 17, 2020
PubMed
Summary

Increased common carotid artery intima-media thickness (CCA-IMT) is linked to a higher risk of ischemic stroke. This marker may help predict stroke events and subtypes, including large versus small vessel disease.

Keywords:
cerebrovascular diseasecommon carotid arteryintima-media thicknessintracerebral haemorrhageischaemic strokemeta-analysisstroke subtypes

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Medical Diagnostics

Background:

  • Common carotid artery intima-media thickness (CCA-IMT) is an early atherosclerosis marker and cardiovascular disease (CVD) predictor.
  • Conflicting findings exist regarding the association between CCA-IMT and stroke risk.

Purpose of the Study:

  • To clarify the association between CCA-IMT and stroke risk, including stroke subtypes.
  • To perform a pooled analysis of published literature on CCA-IMT and stroke.

Main Methods:

  • A comprehensive literature search was conducted across multiple electronic databases (PubMed, Embase, Cochrane Library, etc.).
  • The search covered articles published from January 1950 to April 2020.
  • A meta-analysis was performed on the selected studies.

Main Results:

  • The meta-analysis included 19 studies with 3475 ischemic stroke (IS) cases and 11,826 controls.
  • Increased CCA-IMT showed a strong association with IS risk (SMD = 1.46).
  • Higher risk was observed for large vessel disease (LVD) stroke compared to small vessel disease (SVD) stroke (SMD = 0.36), and for IS compared to intracerebral hemorrhage (ICH) (SMD = 0.71).

Conclusions:

  • CCA-IMT measurements are associated with stroke risk and its subtypes.
  • CCA-IMT may serve as a diagnostic marker for predicting stroke events.