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Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience
Or Dagan1, Assaf Moore2,3, Yuval Nachalon3,4
1Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated with Rappaport Faculty of Medicine, The Technion, Hadera, Israel.
Background:
The role of induction chemotherapy (IC) in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear.
Methods:
A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up-front chemoradiotherapy (CRT).
Results:
Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33 months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21 months, P = .003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco-regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer.
Conclusions:
IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.
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