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Updated: Dec 14, 2025
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Neurocutaneous Melanosis in Infancy: Always a Dismal Prognosis?
Federico Bianchi1, Gianpiero Tamburrini, Cesare Colosimo
1Fondazione Policlinico Gemelli IRCSS, Department of Pediatric Neurosurgery, Rome, Italy.
Aim:
To analyze the current literature on neurocutaneous melanosis (NCM), as well as, our cases, in order to better define the prognosis and the presence of risk factors affecting it, thus, offering better information to the parents.
Material And Methods:
Two cases observed at the Pediatric Neurosurgery Unit of the Catholic University Medical School in Rome are described. Both of them had cutaneous stigmata and cerebral MR evidence of intracranial melanin deposits. These two children showed a very different clinical course.
Results:
The present study enlighten the differences among the two cases and review the literature on the subject, with the attempt to understand which are clinical and disease related factors that might influence the prognosis.
Conclusion:
Beside malignant features of cutaneous melanotic lesions, the presence of hydrocephalus at diagnosis and the early appearance of clinical symptoms, when appearing contemporarily, are predicting the rapid progression of the disease and a worse prognosis.
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