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Published on: March 22, 2024
Neonatal Candida auris infection: Management and prevention strategies - A single centre experience
Jayasree Chandramati1, Laleet Sadanandan1, Anil Kumar2
1Division of Neonatology, Amrita Institute of Medical Sciences, Kochi, India.
Aim:
Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates.
Methods:
This is a retrospective case cohort study of 17 neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive care unit over 3 years. The risk factors, clinical features, treatment and outcome were studied.
Results:
The mean gestation was 32.4 ± 4.9 weeks with overall mortality of 41%. Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to micafungin but resistant to fluconazole and had variable sensitivity to voriconazole and amphotericin. Survival improved to 83% when infants were treated with a combination of micafungin and amphotericin. Non-survivors were of lower birthweights and had other risk factors.
Conclusions:
The management guidelines and infection control measures are described in this largest series of neonatal CA infection. Treatment with a combination of amphotericin and micafungin improved the outcome.
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