Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

869
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
869
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

9.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of the Structure and Dynamics of Water in Aqueous Alkaline Chloride Solutions under Gigapascal Pressure by Neutron Scattering.

The journal of physical chemistry letters·2026
Same author

Association between voltage-gated sodium channel gene polymorphisms and chronic oxaliplatin-induced peripheral neuropathy in Japanese patients with colorectal cancer.

Journal of pharmaceutical health care and sciences·2026
Same author

Usefulness of the Entropy of the Bayesian Posterior Distribution of the Threshold to Assess the Reliability of Measured Visual Field.

Current eye research·2026
Same author

Effect of 2,2,2-trifluoroethyl methacrylate on the gelation characteristics of light-cured soft denture liners based on 2-ethylhexyl methacrylate and acetyl tributyl citrate.

Dental materials journal·2026
Same author

Effects of Optic Nerve Head Structures on Retinal Nerve Fiber Layer Defects in Primary Open Angle Glaucoma Eyes: Analyses Using Retinal Optical Texture Analysis.

American journal of ophthalmology·2026
Same author

Diagnostic Disagreement Between Gonioscopy and Ultrasound Biomicroscopy in Eyes With Occludable Angle.

Journal of glaucoma·2025

Related Experiment Video

Updated: Dec 14, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
04:48

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

3.2K

Improving the Structure-Function Relationship in Glaucomatous Visual Fields by Using a Deep Learning-Based Noise

Ryo Asaoka1, Hiroshi Murata1, Masato Matsuura2

  • 1Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Ophthalmology. Glaucoma
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Processing visual field (VF) measurements with a variational autoencoder (VAE) significantly enhances the structure-function relationship in glaucoma patients. This AI approach improves diagnostic accuracy for detecting glaucoma-related vision loss.

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

Related Experiment Videos

Last Updated: Dec 14, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
04:48

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

3.2K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

Area of Science:

  • Ophthalmology
  • Artificial Intelligence
  • Medical Imaging

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Accurate assessment of the structure-function relationship is crucial for glaucoma diagnosis and management.
  • Current methods may have limitations in fully capturing this relationship.

Purpose of the Study:

  • To evaluate if variational autoencoder (VAE) processing of visual field (VF) data improves the structure-function relationship in glaucoma.
  • To compare the diagnostic performance of VAE-processed VF data with conventional VF measurements.

Main Methods:

  • A VAE model was trained on a large dataset of VF measurements.
  • Optical coherence tomography (OCT) and standard VF tests were performed on glaucoma patients.
  • VAE was used to reconstruct VF data, and the structure-function relationship with circumpapillary retinal nerve fiber layer (cpRNFL) thickness was analyzed.

Main Results:

  • The VAE-reconstructed VF thresholds showed a stronger significant relationship with cpRNFL thickness compared to standard VF thresholds in most sectors.
  • Corrected Akaike information criterion values were improved using VAE-reconstructed data.
  • VAE processing demonstrated enhanced correlation between structural and functional measurements.

Conclusions:

  • Variational autoencoder application to VF data significantly improves the structure-function relationship in glaucoma.
  • This AI-driven approach holds promise for more accurate glaucoma assessment and monitoring.
  • VAE may offer a valuable tool for early detection and management of glaucoma.