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Related Experiment Video

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

Hannah E Suhrs1, Jakob Schroder1, Kira B Bové1

  • 1Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

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|July 17, 2020
PubMed
Summary

Subclinical inflammation is linked to coronary microvascular dysfunction (CMD) and diastolic dysfunction in women. While inflammation impacts CMD, its role in diastolic dysfunction is less clear.

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Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Systemic inflammation and coronary microvascular dysfunction (CMD) are potential causes of heart failure with preserved ejection fraction (HFpEF).
  • Understanding the relationship between inflammation, CMD, and diastolic dysfunction is crucial for HFpEF research.

Purpose of the Study:

  • To investigate the association between subclinical inflammation and non-endothelial dependent CMD.
  • To explore the link between inflammation and diastolic dysfunction.

Main Methods:

  • Cross-sectional study of 336 women with angina and 95 controls.
  • Analysis of 90 biomarkers, including 34 inflammatory markers.
  • Assessment of CMD using coronary flow velocity reserve (CFVR) and diastolic function via E/e'.

Main Results:

  • Coronary microvascular dysfunction (CMD) was prevalent (59%) in participants.
  • Numerous inflammatory biomarkers correlated with both reduced CFVR and increased E/e'.
  • A significant association between CFVR and E/e' was observed only in patients with CMD and elevated filling pressures.

Conclusions:

  • This study establishes a link between inflammatory biomarkers, CMD, and diastolic function indicators.
  • Inflammation plays a role in CMD, but its direct pathophysiological role in diastolic dysfunction requires further investigation.
  • The high prevalence of CMD contrasts with the low incidence of diastolic dysfunction, suggesting complex underlying mechanisms.