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Antifouling molecularly imprinted membranes for pretreatment of milk samples: Selective separation and detection of
Zeqing Dong1, Jian Lu1, Yilin Wu1
1Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Abstract:
As a veterinary antibiotic, lincomycin (LIN) residues in milk are raising concerns of public on account of potential harm to human health. Efficient strategy is eagerly desired for detection of LIN from milk samples. Hence, lincomycin molecularly imprinted membranes (LINMIMs) were developed for selective separation of LIN as an efficient pretreatment of milk samples. The synergistic effect of polyethylenimine and dopamine provided effective antifouling performance by improving the hydrophilicity. Based on click chemistry, specific recognition sites were facilely formed on membranes using 4-vinylpyridine as functional monomers. The satisfactory rebinding capacity (151.62 mg g-1), permselectivity (4.43), together with the linear dependence (R2 = 0.9902) of concentrations in eluents and original samples. Moreover, the method was utilized to determine LIN from milk, with good recovery and relative standard deviation. Achievements in this work will actively promote the development of efficient detection technology.
Insights
New lincomycin molecularly imprinted membranes (LINMIMs) offer efficient detection of lincomycin (LIN) antibiotic residues in milk. This advancement improves milk safety and public health by enabling sensitive and selective LIN analysis.
Area of Science:
- Analytical Chemistry
- Materials Science
- Food Safety
Background:
- Veterinary antibiotic lincomycin (LIN) residues in milk pose risks to human health.
- Sensitive and efficient detection methods for LIN in milk are crucial for public safety.
Purpose of the Study:
- To develop lincomycin molecularly imprinted membranes (LINMIMs) for selective LIN separation and detection in milk.
- To enhance antifouling properties and recognition capabilities of the membranes.
Main Methods:
- Fabrication of LINMIMs using click chemistry and 4-vinylpyridine functional monomers.
- Incorporation of polyethylenimine and dopamine for improved hydrophilicity and antifouling.
- Evaluation of membrane performance including rebinding capacity, permselectivity, and linearity.
Main Results:
- LINMIMs demonstrated a high rebinding capacity (151.62 mg g⁻¹).
- Excellent permselectivity (4.43) and linear concentration dependence (R² = 0.9902) were achieved.
- The developed method showed good recovery and relative standard deviation for LIN determination in milk.
Conclusions:
- LINMIMs provide an effective pretreatment strategy for selective LIN separation from milk.
- The developed method offers a reliable approach for detecting LIN residues, promoting food safety.
- This work contributes to advancing efficient analytical technologies for veterinary drug residue monitoring.
