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Standardising definitions for the pre-eclampsia core outcome set: A consensus development study.

James M N Duffy1, Alexandra E Cairns2, Laura A Magee3

  • 1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom; Institute for Women's Health, University College London, London, United Kingdom.

Pregnancy Hypertension
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Consensus definitions for pre-eclampsia core outcomes were established, including specific considerations for low- and middle-income countries. This standardization aims to improve consistency in research and clinical practice.

Keywords:
Consensus development studyCore outcome setHypertension in pregnancyOutcome measurePre-eclampsiaRandomised controlled trials

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Area of Science:

  • Obstetrics and Gynecology
  • Clinical Trial Methodology
  • Global Health

Background:

  • Pre-eclampsia research lacks standardized outcome definitions, hindering evidence synthesis and clinical application.
  • Existing definitions vary across guidelines and trials, leading to inconsistencies in research findings.
  • Standardized definitions are crucial for improving the quality and comparability of pre-eclampsia research.

Purpose of the Study:

  • To develop consensus definitions for the core outcome set in pre-eclampsia research.
  • To ensure consistency in outcome measurement across studies.
  • To facilitate the translation of research findings into clinical practice.

Main Methods:

  • A comprehensive review of existing definitions from initiatives, guidelines, systematic reviews, and randomized trials.
  • A consensus development meeting involving healthcare professionals and researchers, with representation from low- and middle-income countries.
  • International steering group approval of the final core outcome set.

Main Results:

  • Consensus definitions were successfully developed for all core outcomes related to pre-eclampsia.
  • Specific definitions were created for stroke, pulmonary edema, acute kidney injury, elevated liver enzymes, low platelet count, birth weight, and neonatal seizures.
  • Definitions were tailored for low- and middle-income countries, considering limitations in diagnostic interventions.

Conclusions:

  • The established consensus definitions will standardize measurements in pre-eclampsia core outcome sets.
  • This standardization is expected to enhance consistency in future randomized trials and systematic reviews.
  • Improved research accessibility and translation into clinical practice are anticipated outcomes.