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Leiomyosarcoma After Liver Transplantation Is Unrelated to Epstein-Barr Virus: A Case Report
1Liver Transplant Center, Beijing Friendly Hospital, Capital Medical University, Beijing, China.
Background:
De novo malignancy is a severe complication after liver transplantation (LT), but de novo leiomyosarcoma is extremely rare.
Methods:
We reported de novo leiomyosarcoma occurring after LT. The patient's status for Epstein-Barr virus was negative. The donor was a 21-year-old man with a central nervous system malignancy who underwent surgery. Three months later brain death occurred and his organs were donated.
Results:
Leiomyosarcoma in the recipient was detected shortly after LT. It progressed after minimization of immunosuppression and apatinib therapy, and the patient died of cachexia 17 months after LT.
Conclusions:
De novo leiomyosarcoma is a rare but serious event after LT, needing comprehensive management.
