Related Experiment Video
Updated: Dec 14, 2025
A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer
Published on: August 19, 2025
[Surgical management of resectable non-small cell lung cancer: Towards new paradigms]
Mathilde Prieto1, Antonio Bobbio1, Ludovic Fournel1
1AP-HP Centre, UNIVERSITE de Paris, hôpital Cochin, service de chirurgie thoracique, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Abstract:
Adapting therapies and providing personalized care for patients with resectable non-small cell lung cancer represent major challenges. This involves integrating several parameters into the patient's management, not only crude pathologic results, but also a better understanding of the mechanisms involved in tumor progression. Many studies have looked at the impact of host and tumor characteristics and their interactions through inflammatory processes or tumor immune environment. Beyond tumor stage, poor nutrition, sarcopenia and inflammatory state have been identified as independent factors that can directly impact postoperative outcome. The development of Enhanced Recovery After Surgery (ERAS), in which patient becomes the main player in their own management, seems to be an interesting answer since it seems to allow a reduction in postoperative complications, length of stay and indirectly reduction in costs. A broader and more complete vision including morphometric evaluation of the patient, physical performances, inflammatory state and nutritional state would provide additional discriminating information which can predict postoperative outcome and help in adapting therapies in a personalized way.
Insights
Personalized care for resectable non-small cell lung cancer requires integrating patient factors beyond pathology. A holistic approach, including nutrition and inflammation, improves postoperative outcomes and treatment adaptation.
Area of Science:
- Oncology
- Surgical Outcomes
- Personalized Medicine
Background:
- Resectable non-small cell lung cancer (NSCLC) treatment adaptation and personalized care face challenges.
- Host and tumor characteristics, including inflammatory processes and tumor immune microenvironment, influence progression.
- Factors beyond tumor stage, such as poor nutrition, sarcopenia, and inflammatory status, independently impact postoperative outcomes.
Purpose of the Study:
- To explore the integration of comprehensive patient parameters for personalized therapy in resectable NSCLC.
- To evaluate the potential of a holistic patient assessment in predicting postoperative outcomes.
- To identify strategies for adapting therapies based on a broader understanding of patient status.
Main Methods:
- Review of studies examining host and tumor characteristics in NSCLC.
- Analysis of factors influencing postoperative outcomes, including nutrition, sarcopenia, and inflammation.
- Exploration of the Enhanced Recovery After Surgery (ERAS) pathway's role.
Main Results:
- Poor nutrition, sarcopenia, and inflammatory state are identified as independent predictors of poor postoperative outcomes in NSCLC.
- Enhanced Recovery After Surgery (ERAS) protocols show promise in reducing complications and hospital stay.
- A comprehensive patient evaluation, including morphometric, physical, inflammatory, and nutritional states, offers discriminating predictive information.
Conclusions:
- Personalized care for resectable NSCLC necessitates integrating diverse patient parameters beyond traditional pathological staging.
- A holistic assessment approach, incorporating nutritional status, sarcopenia, and inflammatory markers, is crucial for predicting and improving surgical outcomes.
- Implementing comprehensive patient evaluations can guide adaptive therapeutic strategies and enhance postoperative recovery.
