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Updated: Dec 14, 2025
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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DECONSTRUCTING EXTRAPLACENTAL MEMBRANES TO UNDERSTAND BACTERIAL CHORIOAMNIONITIS.
1NASHVILLE, TENNESSEE.
Summary
Bacterial chorioamnionitis, an intrauterine infection, can cause preterm labor and fetal complications. Researchers are using organ-on-chip models to study early host-microbe interactions in this silent disease.
Area of Science:
- Reproductive Biology
- Infectious Diseases
- Biomedical Engineering
Background:
- Bacterial chorioamnionitis is an intrauterine infection ascending from the vagina.
- It can lead to preterm labor, fetal stillbirth, and newborn infections.
- Affected infants face increased risks of lifelong disability.
Purpose of the Study:
- To define early host-microbe interactions in bacterial chorioamnionitis pathogenesis.
- To identify critical factors in the development of intrauterine infections.
- To inform better diagnostic, therapeutic, and preventive strategies.
Main Methods:
- Utilizing organ-on-chip models of human fetal membranes.
- Investigating host-microbe interactions at the initial stages of infection.
- Employing team science approaches for comprehensive analysis.
Main Results:
- Early microbial contact with fetal membranes is a key focus.
- Organ-on-chip models allow detailed study of pathogenesis.
- Host-microbe interactions are critical to disease development.
Conclusions:
- Understanding early pathogenesis is crucial for combating chorioamnionitis.
- Organ-on-chip technology offers a novel platform for studying intrauterine infections.
- Further research is needed to develop improved interventions.
