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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.1K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.1K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.3K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.1K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.0K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.0K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.1K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.2K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Related Experiment Video

Updated: Dec 14, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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NOTCH SIGNALING IN CONTEXT: BASIC AND TRANSLATIONAL IMPLICATIONS.

Jon C Aster1

  • 1BOSTON, MASSACHUSETTS.

Transactions of the American Clinical and Climatological Association
|July 18, 2020
PubMed
Summary
This summary is machine-generated.

Notch signaling, crucial for cell behavior and cancer, is modulated by epigenetic landscapes. Understanding these "rules" is key to developing safe and effective Notch-targeted therapies.

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Last Updated: Dec 14, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Area of Science:

  • Cellular biology
  • Molecular oncology
  • Epigenetics

Background:

  • The Notch signaling pathway is a conserved mechanism regulating cellular behavior, development, and tissue homeostasis.
  • Dysregulation of Notch signaling is implicated in various human diseases, especially cancer.
  • Therapeutic targeting of Notch is challenging due to incomplete understanding of its activation outcomes and potential toxicity.

Purpose of the Study:

  • To investigate how Notch signaling influences the behavior of diverse cancer cell types.
  • To elucidate the regulatory mechanisms governing Notch pathway functions in cancer.

Main Methods:

  • Utilized well-controlled experimental systems to study Notch signaling in cancer cells.
  • Investigated the interplay between Notch activation and epigenetic landscapes.

Main Results:

  • Notch signaling outcomes are determined by epigenetic landscapes established by pioneer transcription factors.
  • These transcription factors delineate the specific effects of Notch activation.

Conclusions:

  • The findings provide insights into the functional rules of Notch signaling in cancer.
  • This research represents a step towards developing safe and effective Notch-targeted cancer therapies.