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Related Experiment Video

Updated: Dec 14, 2025

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Cutaneous signet-ring cell squamous cell carcinoma.

Sarah K Findeis1, Allison Readinger1, James Mitchell2

  • 1Department of Pathology, Baylor University Medical CenterDallasTexas.

Proceedings (Baylor University. Medical Center)
|July 18, 2020
PubMed
Summary

A rare cutaneous signet-ring cell squamous cell carcinoma (SRCSCC) case in a transgender woman highlights its aggressive features. This finding expands understanding of this uncommon skin cancer variant.

Keywords:
Signet-ring cell squamous cell carcinomasignet squamous cell

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Area of Science:

  • Dermatopathology
  • Oncology
  • Medical Case Reports

Background:

  • Cutaneous signet-ring cell squamous cell carcinoma (SRCSCC) is an exceptionally rare variant of squamous cell carcinoma.
  • It predominantly affects the head and neck region, with limited existing literature.
  • Understanding its presentation and behavior is crucial for accurate diagnosis and management.

Observation:

  • A case study of a 66-year-old transgender woman presenting with a large, ulcerated facial mass (5.6 × 4.0 × 2.0 cm).
  • Histopathological examination confirmed features consistent with SRCSCC.
  • The tumor demonstrated perineural, lymphovascular, and subcutaneous invasion.

Findings:

  • Immunohistochemistry revealed positive staining for high-molecular-weight cytokeratin, p40, and estrogen receptor (ER), with partial loss of E-cadherin.
  • Negative staining for Ber EP-4, cytokeratin 7, low-molecular-weight cytokeratin, mucicarmine, Alcian blue PAS, HER2, and MUC4.
  • Microsatellite instability testing was negative.

Implications:

  • This case contributes valuable data to the sparse knowledge base of cutaneous signet-ring cell squamous cell carcinoma.
  • The findings underscore the aggressive potential of SRCSCC, even in unusual demographic presentations.
  • Further research is warranted to elucidate the specific characteristics and optimal treatment strategies for this rare entity.