Quadruple therapy for gastric high-grade B-cell lymphoma
Ted George Achufusi1, Kegan Jessamy1, Ernesto Zamora1
1Department of Internal Medicine, State University of New York Upstate Medical UniversitySyracuseNew York.
Proceedings (Baylor University. Medical Center)
|July 18, 2020
Summary
Most gastric lymphomas linked to Helicobacter pylori (H. pylori) infection respond to eradication. This case shows a high-grade lymphoma also achieved remission after H. pylori treatment.
Area of Science:
- Gastroenterology
- Oncology
- Infectious Diseases
Background:
- Mucosa-associated lymphoid tissue (MALT) lymphomas of the stomach are often linked to Helicobacter pylori infection.
- H. pylori eradication is a standard treatment for low-grade gastric MALT lymphomas, leading to long-term remission.
- High-grade gastric lymphomas, while sometimes associated with H. pylori, typically do not respond to eradication therapy.
Observation:
- A patient presented with high-grade diffuse large B-cell lymphoma of the stomach.
- The patient's condition was potentially associated with H. pylori infection.
Findings:
- Complete remission was achieved in the patient following H. pylori eradication therapy.
- This suggests a potential therapeutic role for H. pylori eradication in select cases of high-grade gastric lymphoma.
Implications:
- H. pylori eradication may be a viable treatment option for certain high-grade gastric lymphomas.
- Further research is warranted to explore the efficacy of H. pylori eradication in high-grade gastric lymphomas.
- This finding could alter treatment strategies for gastric lymphomas.
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