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Published on: March 24, 2019
The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
Jiayan Jin1,2, Xiaoxuan Zhao1,2, Huifang Fu1,3
1Department of Forensic Science, School of Basic Medical Science, Wenzhou Medical University, Wenzhou, China.
Abstract:
Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration, and apoptosis. However, the roles and underlying mechanisms of YAP in CNS diseases are still puzzling. Here, this review will systematically and comprehensively summarize the biological feature, pathological role, and underlying mechanisms of YAP in normal and pathologic CNS, which aims to provide insights into the potential molecular targets and new therapeutic strategies for CNS diseases.
Insights
Yes-associated protein (YAP), a key part of the Hippo pathway, is vital for central nervous system (CNS) function. This review explores YAP
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- Yes-associated protein (YAP) is a critical downstream effector of the Hippo signaling pathway.
- YAP significantly influences central nervous system (CNS) physiology and pathology.
- Its precise roles and mechanisms in CNS diseases remain largely unclear.
Purpose of the Study:
- To systematically review the biological features of YAP in the CNS.
- To elucidate the pathological roles and underlying mechanisms of YAP in both normal and diseased CNS.
- To identify potential molecular targets and therapeutic strategies for CNS disorders.
Main Methods:
- Comprehensive literature review of YAP in the central nervous system.
- Analysis of YAP's involvement in cell proliferation, differentiation, migration, and apoptosis.
- Synthesis of current knowledge on YAP's function in CNS diseases.
Main Results:
- YAP regulates fundamental cellular processes in the CNS, including proliferation, differentiation, migration, and apoptosis.
- Evidence suggests YAP plays a complex role in various CNS pathologies.
- Specific molecular mechanisms linking YAP to CNS disease pathogenesis are being uncovered.
Conclusions:
- YAP is a crucial regulator in the CNS with significant implications for disease.
- Understanding YAP's mechanisms offers potential for novel therapeutic interventions in CNS diseases.
- Further research into YAP's role could lead to targeted treatments for neurological disorders.
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