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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Neuroplasticity01:01

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Antiepileptic Drugs: Glutamate Antagonists01:14

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:05

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Dec 14, 2025

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
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Homeostatic Plasticity in Epilepsy.

Gabriele Lignani1, Pietro Baldelli2,3, Vincenzo Marra4

  • 1Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, University College London, London, United Kingdom.

Frontiers in Cellular Neuroscience
|July 18, 2020
PubMed
Summary

Epilepsy may stem from failures in the brain's natural ability to regulate neuronal network activity, known as homeostatic plasticity. Understanding this process is key to developing new epilepsy treatments.

Keywords:
REST (RE-1 silencing transcription factor)epilepsyexcitation inhibition balancegene therapyhomeostatic plasticitysynaptic transmission

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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
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Related Experiment Videos

Last Updated: Dec 14, 2025

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Homeostatic Plasticity

Background:

  • Neuronal excitability and synaptic strength are vital for healthy brain function, maintained by homeostatic regulation.
  • Epilepsy involves synchronized neuronal firing due to a breakdown in regulating network activity.
  • The role of homeostatic compensation in epilepsy pathogenesis and chronic phases remains debated with limited experimental evidence.

Purpose of the Study:

  • To discuss recent findings on the role of homeostatic plasticity in epilepsy.
  • To explore how homeostatic compensation influences epileptogenesis and the chronic phase of epilepsy.
  • To highlight the significance of homeostatic plasticity in epilepsy therapeutic interventions.

Main Methods:

  • Review and discussion of recent scientific literature and proposed theories.
  • Analysis of experimental evidence related to homeostatic plasticity in epilepsy models.
  • Examination of the temporal regulation and pathological progression of homeostatic compensations.

Main Results:

  • Homeostatic compensations are likely active before and during epileptogenesis, with temporally regulated actions dependent on pathology progression.
  • Transcriptional regulation plays a dual role during epileptogenesis.
  • The epileptic brain may counteract classic pharmacological interventions, suggesting a need for novel therapeutic strategies.

Conclusions:

  • Homeostatic plasticity is crucial in understanding epilepsy development and progression.
  • Dysfunctional homeostatic mechanisms contribute to epileptogenesis.
  • Novel therapeutic approaches targeting homeostatic plasticity may restore physiological balance in epilepsy.