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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Mechanisms of Retrovirus-induced Cancers01:51

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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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The Ras Gene02:38

The Ras Gene

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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Related Experiment Video

Updated: Dec 14, 2025

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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Circular RNAs in Blood Malignancies.

Olivia Perez de Acha1, Martina Rossi1, Myriam Gorospe1

  • 1Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.

Frontiers in Molecular Biosciences
|July 18, 2020
PubMed
Summary

Circular RNAs (circRNAs) are key regulators in blood cancers, influencing tumor growth and treatment resistance. This review highlights their roles in various leukemias and lymphomas, suggesting potential as diagnostic and therapeutic targets.

Keywords:
blood malignanciescircular RNAsleukemiaslymphomasnon-coding RNA

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Related Experiment Videos

Last Updated: Dec 14, 2025

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are crucial regulators of biological processes through interactions with proteins and microRNAs.
  • CircRNAs in the hematopoietic system modulate physiological and pathological features of hematopoietic stem cell (HSC)-derived populations.
  • Specific circRNAs can promote or inhibit tumor progression in blood cancers like leukemia and lymphoma.

Purpose of the Study:

  • To review significant circRNAs in major hematologic malignancies.
  • To discuss the diagnostic and prognostic potential of circRNAs.
  • To explore circRNAs as therapeutic targets in blood cancers.

Main Methods:

  • Literature review of circRNAs in hematologic malignancies.
  • Analysis of circRNA roles in tumor progression and treatment resistance.
  • Discussion of circRNA biomarker and therapeutic potential.

Main Results:

  • Numerous circRNAs identified in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphomas, and multiple myeloma (MM).
  • Evidence suggests circRNAs impact tumor progression and confer resistance to conventional therapies.
  • CircRNAs show promise as diagnostic and prognostic indicators.

Conclusions:

  • CircRNAs are significant players in the pathogenesis and treatment of hematologic cancers.
  • CircRNAs represent promising biomarkers for diagnosis and prognosis.
  • Targeting circRNAs offers a potential novel therapeutic strategy for blood malignancies.