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Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis
James Brett Case1, Paul W Rothlauf2,3, Rita E Chen1,4
1Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Biorxiv : the Preprint Server for Biology
|July 18, 2020
Summary
A novel vesicular stomatitis virus (VSV)-based vaccine expressing the SARS-CoV-2 spike gene demonstrated protection in mice against COVID-19. This replication-competent vaccine candidate elicits neutralizing antibodies and reduces viral load and lung inflammation.
Area of Science:
- Virology
- Immunology
- Vaccinology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with significant mortality.
- Effective vaccines are crucial for controlling coronavirus disease 2019 (COVID-19).
Conclusions:
- VSV-eGFP-SARS-CoV-2 is an effective replication-competent vaccine candidate against SARS-CoV-2.
- The vaccine elicits robust neutralizing antibody responses and confers protection against COVID-19 in a preclinical model.
- Further development of this VSV-based vaccine is warranted for potential use against SARS-CoV-2.
