Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

485
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
485
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

469
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
469
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

669
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
669
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

429
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
429
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

114
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
114
Borderline Personality Disorder01:25

Borderline Personality Disorder

373
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
373

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is everyone looking at me? The perception of direct gaze as a potential cognitive marker in social anxiety and its moderation by emotional expression.

Journal of affective disorders·2026
Same author

An integrative mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression.

Translational psychiatry·2026
Same author

Understanding tonic and phasic irritability in developmental psychopathology among help-seeking children and adolescents in Switzerland: Protocol for the longitudinal multimodal UTOPICA study.

BMJ open·2026
Same author

Behavioral Activation as a Principle-Based Treatment: Developments from a Multi-Site Collaboration to Advance Adolescent Depression Treatment.

Evidence-based practice in child and adolescent mental health·2026
Same author

Cross-Cultural Consortium on Irritability (C3I): An International Network for Research on Cultural Similarities and Differences in Irritability.

JAACAP open·2026
Same author

Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders.

Communications biology·2026

Related Experiment Video

Updated: Dec 14, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.1K

Debate: Pediatric bipolar disorder - divided by a common language?

Argyris Stringaris1

  • 1Mood Brain and Development Unit, National Institutes of Health, Bethesda, MD, USA.

Child and Adolescent Mental Health
|July 18, 2020
PubMed
Summary

The debate surrounding pediatric bipolar disorder (pBD) highlights significant diagnostic variations within the United States, challenging European perceptions of it being a mere fad. Early diagnosis and treatment are crucial for children experiencing manic and depressive episodes.

More Related Videos

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.5K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.2K

Related Experiment Videos

Last Updated: Dec 14, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.1K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.5K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.2K

Area of Science:

  • Child and Adolescent Psychiatry
  • Mental Health Services Research
  • Transatlantic Medical Debates

Background:

  • The diagnosis of pediatric bipolar disorder (pBD) is often viewed as a transatlantic controversy.
  • This perspective is Eurocentric and overlooks significant intra-American diagnostic variations.

Purpose of the Study:

  • To analyze the transatlantic debate surrounding pediatric bipolar disorder (pBD).
  • To highlight the internal inconsistencies in pBD diagnosis within the United States.
  • To challenge the notion of pBD as a 'New World fad' and underscore the need for appropriate treatment.

Main Methods:

  • Analysis of the historical and conceptual development of the pBD debate.
  • Examination of diagnostic practices and their geographical variations within the US.
  • Critique of European responses to the rise of pBD diagnoses.

Main Results:

  • Significant diagnostic disparities for pBD exist between US states.
  • European dismissal of pBD as a fad was inaccurate.
  • Children with pBD symptoms were historically misdiagnosed or dismissed in some regions.

Conclusions:

  • The pBD debate is complex, influenced by US internal diagnostic variations.
  • Early recognition and treatment of pBD in children are essential.
  • Overcoming outdated diagnostic approaches is critical for effective pediatric mental healthcare.