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Updated: Dec 14, 2025

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Debate: No bipolar disorder in prepubertal children at high familial risk
1Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Abstract:
The rise in pediatric bipolar disorder (PBD) prevalence rates and the related treatment regimen has an impact on a whole generation of severely affected young children. In Europe, we also see these emotional dysregulated children with a broad range of explosive disruptive behavior. However, classification within the bipolar disorder spectrum is rare. Why are these prepubertal children diagnosed with mania and how does this fit with the findings from bipolar offspring studies? Impact of methods of assessment, recruitment, and parental diagnoses are discussed.
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