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Updated: Dec 14, 2025

In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
Implant Retention or Removal for Management of Surgical Site Infection After Spinal Surgery
Aakash Agarwal1, Amey Kelkar1, Ashish G Agarwal2
1University of Toledo, Toledo, OH, USA.
Study Design:
A literature review.
Objective:
To summarize the implant removal rate, common bacterial organisms found, time of onset, ratio of superficial to deep infection, and regurgitating the prevalence among all the retrospective and prospective studies on management and characterization of surgical site infections (SSIs).
Methods:
PubMed was searched for articles published between 2000 and 2018 on the management or characterization of SSIs after spinal surgery. Only prospective and retrospective studies were included.
Results:
A total of 49 articles were found relevant to the objective. These studies highlighted the importance of implant removal to avoid recurrence of SSI. The common organisms detected were methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermis, Staphylococcus epidermis, Staphylococcus aureus, and Propionibacterium acnes, with prevalence of 1% to 15%. A major proportion of all were deep SSI, with minority reporting on late-onset SSI.
Conclusion:
Long-term antibiotics administration, and continuous irrigation and debridement were common suggestion among the authors; however, the key measure undertaken or implied by most authors to avoid risk of recurrence was removal or replacement of implants for late-onset SSI.
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