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Altered brain structural and functional connectivity in schizotypy.

Yong-Ming Wang^1,2,3,4, Xin-Lu Cai^1,2,3,4, Rui-Ting Zhang^1,4

¹Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing100101, PR China.

Psychological Medicine

|July 18, 2020

Summary

This summary is machine-generated.

Individuals with high schizotypy show altered brain connectivity, including increased structural connectivity and altered functional connectivity in key networks. These changes suggest complex neurobiological underpinnings for schizophrenia-like traits.

Keywords:

Connectivity decompensation hypothesis dynamic functional connectivity schizotypy static functional connectivity structural connectivity probability

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Area of Science:

Neuroscience
Psychiatry
Brain Imaging

Background:

Schizotypy involves schizophrenia-like traits below clinical thresholds.
Schizophrenia's development may involve brain disconnection and compensatory/decompensatory connectivity changes.

Purpose of the Study:

To investigate brain connectivity alterations in individuals with high schizotypy.
To combine structural and functional connectivity analyses.

Main Methods:

Utilized diffusion tensor imaging and resting-state fMRI.
Analyzed white matter structural connectivity, static and dynamic functional connectivity.
Compared 87 high schizotypy individuals with 122 controls across 264 brain regions.

Main Results:

Increased structural connectivity in task control and default mode networks.
Altered functional connectivity (variability, stability) in default mode, auditory, and subcortical networks.
Decreased static functional connectivity in sensorimotor, default mode, and task control networks.

Conclusions:

High schizotypy is associated with specific brain connectivity changes.
Both compensatory and decompensatory connectivity changes may underlie schizotypy.
These connectivity alterations are potential neurobiological correlates of high schizotypy.