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Use of Antimicrobial Agents in Hospitalized Children for Noninfectious Indications

Preeti Jaggi1, Rana F Hamdy2, Brian Lee3

  • 1Division of Infectious Diseases, Department of Pediatrics, Emory University, Atlanta, Georgia.

Journal of the Pediatric Infectious Diseases Society
|July 18, 2020
PubMed

Insights

A study found 1.7% of hospitalized children received antimicrobials for non-infection reasons, with macrolides most common. Antimicrobial stewardship needs to address this prescribing practice and its effects.

Area of Science:

  • Pediatric hospital medicine
  • Infectious diseases
  • Antimicrobial stewardship

Background:

  • Antimicrobial agents are crucial for treating infections.
  • Inappropriate antimicrobial use contributes to resistance and adverse events.
  • Understanding non-infection-related antimicrobial prescribing in children is essential.

Purpose of the Study:

  • To determine the prevalence of antimicrobial use for non-infection-related reasons in hospitalized children.
  • To identify common antimicrobial classes used inappropriately.
  • To highlight the need for stewardship interventions.

Main Methods:

  • Point-prevalence study design.
  • Data collected from 32 US children's hospitals.
  • Analysis of antimicrobial prescribing patterns.

Main Results:

  • 1.7% of hospitalized children received at least one antimicrobial agent for a non-infection-related reason.
  • Macrolides were the most commonly prescribed class for these indications.
  • Significant variation in prescribing practices was observed.

Conclusions:

  • Non-infection-related antimicrobial prescribing is a notable issue in pediatric hospitals.
  • Antimicrobial stewardship programs must address these prescribing practices.
  • Further research is needed on the impact of these practices.

Keywords:
antimicrobial stewardshipgastrointestinal motilitymacrolide

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