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Compressed-sensing accelerated 4D flow MRI of cerebrospinal fluid dynamics
Elena Jaeger1, Kristina Sonnabend2, Frank Schaarschmidt3
1Department of Diagnostic and Interventional Radiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Street 62, 50937, Cologne, Germany.
Fluids and Barriers of the CNS
|July 18, 2020
Summary
Compressed SENSE accelerated MRI significantly reduces spinal cerebrospinal fluid (CSF) flow measurement times. This technique allows for accurate analysis of CSF hydrodynamics within clinically acceptable durations.
Area of Science:
- Medical Imaging
- Neurology
- Biophysics
Background:
- 4D flow MRI of cerebrospinal fluid (CSF) is crucial for understanding neurological diseases.
- Current clinical applications are limited by lengthy acquisition times.
Purpose of the Study:
- To evaluate the accuracy of compressed SENSE accelerated MRI for spinal CSF flow.
- To assess the impact of acceleration factors on measurement accuracy and scan time.
Main Methods:
- 20 healthy subjects underwent 4D flow MRI of cervical CSF using compressed SENSE (CSE) with acceleration factors 4-10.
- Conventional SENSE scans served as reference.
- Peak velocity, net flow, forward, and backward flow were analyzed using Bland-Altman analysis.
Main Results:
- Acquisition times were reduced by up to 40% with CSE (e.g., CSE6: 6:25 min vs. SENSE: 10:21 min).
- Good agreement was found for peak velocity.
- Slight overestimations (<1 ml/min) in net, forward, and backward flow were observed for CSE4-8.
Conclusions:
- Compressed SENSE (CSE) with acceleration factors up to 6 is feasible for spinal CSF flow MRI.
- This acceleration enables clinically viable scan times for comprehensive CSF flow dynamics analysis.
