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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV2 and pregnancy: An invisible enemy?
Sonam Verma1,2, Ebony B Carter1,2, Indira U Mysorekar1,2
1Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Summary
This review examines placental findings and pregnancy outcomes in COVID-19, including related coronaviruses. Understanding SARS-CoV-2 in pregnancy can inform therapeutic interventions.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pathology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has emerged globally.
- Limited data exist on COVID-19's impact on pregnancy and fetal outcomes.
- Severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS) provide context for pathogenic coronaviruses in pregnancy.
Purpose of the Study:
- To review pathological findings in placentas from SARS-CoV-2 positive women.
- To analyze pregnancy outcomes associated with SARS-CoV-2, SARS-CoV, and MERS.
- To explore immune-inflammatory factors and the Renin Angiotensin System in COVID-19 pregnancy.
Main Methods:
- Literature review of pathological placental findings in COVID-19.
- Review of pregnancy outcomes from SARS-CoV-2, SARS-CoV, and MERS cases.
- Synthesis of data on immune-inflammatory correlates and Renin Angiotensin System in pregnancy.
Main Results:
- Pathological findings in placentas from women with COVID-19 are examined.
- Information on pregnancy outcomes related to SARS-CoV-2 and other pathogenic coronaviruses is compiled.
- Immune-inflammatory correlates and the Renin Angiotensin System's role in COVID-19 pathogenesis during pregnancy are discussed.
Conclusions:
- Understanding SARS-CoV-2 pathogenesis in the placenta is crucial.
- Insights gained can guide therapeutic interventions for pregnant women with COVID-19.
- Further research is needed to fully elucidate COVID-19's effects on pregnancy.
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