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Review on druggable targets of key age-associated properties regulated by therapeutic agents

Ambili Unni P1, Sajitha Lulu Sudhakaran1, Girinath G Pillai1,2

  • 1School of Biosciences and Technology, VIT, Vellore, India.

Chemical Biology & Drug Design
|July 18, 2020
PubMed

Insights

Aging causes physiological decline and age-related diseases, often linked to mitochondrial dysfunction and oxidative stress. This review explores druggable targets for anti-aging therapies like antioxidants and immunomodulators to enhance efficacy.

Area of Science:

  • Gerontology and molecular biology
  • Biomedical sciences
  • Pharmacology

Background:

  • Aging is characterized by physiological deterioration, increasing susceptibility to diseases like neurodegenerative, cardiovascular, and immunomodulatory conditions.
  • Mitochondrial dysfunction in aging contributes to reactive oxygen species production, a key factor in age-associated pathologies.
  • The growing prevalence of age-related diseases necessitates the development of potent and bioavailable therapeutic agents.

Purpose of the Study:

  • To review the druggable targets associated with key anti-aging properties of therapeutic agents.
  • To provide insights into therapeutic strategies targeting antioxidant, immunomodulatory, cardioprotective, anti-melanogenic, and anti-elastase effects.
  • To facilitate the development of novel therapeutic agents and supplements for enhanced efficacy in combating aging.

Main Methods:

  • Literature review of scientific articles and research papers on aging and therapeutic targets.
  • Analysis of biological mechanisms underlying age-related diseases.
  • Identification and categorization of druggable targets for various anti-aging properties.

Main Results:

  • Druggable targets for antioxidant, immunomodulation, cardioprotection, anti-melanogenic, and anti-elastase properties were identified.
  • Understanding disease mechanisms provides insights into effective therapeutic interventions.
  • The review consolidates information on targets relevant to the initiation and progression of age-related diseases.

Conclusions:

  • Targeting specific pathways related to aging can lead to the development of effective therapeutic agents.
  • Enhanced understanding of druggable targets is crucial for designing novel anti-aging drugs and supplements.
  • This review offers a comprehensive overview to guide future research in gerontology and therapeutic development.
Keywords:
Agingage-associated diseasesdruggable targetsmitochondrial dysfunctionsreactive oxygen species

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