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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

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Optimization for customized trajectories in cone beam computed tomography.

Sepideh Hatamikia^1,2, Ander Biguri³, Gernot Kronreif¹

¹Austrian Center for Medical Innovation and Technology, Wiener Neustadt, Austria.

Medical Physics

|July 18, 2020

Summary

This summary is machine-generated.

Optimized cone beam computed tomography (CBCT) trajectories reduce projection numbers by 75% while maintaining image quality. This enables efficient, targeted imaging for interventions with spatial constraints.

Keywords:

cone beam computed tomography (CBCT)image-guided therapy (IGT)limited angle noncircular scan orbits source-detector trajectory optimization tomographic reconstruction

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Area of Science:

Medical Imaging
Image Reconstruction
Cone Beam Computed Tomography (CBCT)

Background:

Standard CBCT utilizes circular trajectories, requiring numerous projections.
Kinematic constraints in patient positioning can limit traditional CBCT scanning.
Prior image information can guide trajectory optimization for targeted imaging.

Purpose of the Study:

To develop a target-based framework for optimizing 3D CBCT source-detector trajectories.
To enable topical information acquisition using limited-angle, noncircular orbits with minimal projections.
To reconstruct specific volumes of interest (VOI) under kinematic constraints.

Main Methods:

Utilized patient-specific CT data as a digital phantom for trajectory simulations.
Optimized projection views by maximizing an objective function based on imaging quality.
Evaluated performance using phantoms and quantified image quality with FWHMavg, FSIM, UQI, and CNR.

Main Results:

Optimized trajectories achieved comparable image quality to standard CBCT using ~25% of projections.
Relative deviations in image quality metrics (FWHMavg, FSIM, UQI, CNR) were below 9%.
Optimized trajectories outperformed partial circular trajectories, typically using 116°-152° angular range.

Conclusions:

Limited-angle, noncircular CBCT trajectories with optimized orientations provide suitable image quality.
This approach has potential for limited-angle, low-dose CBCT interventions under spatial constraints.