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Change in metabolic parameters and weight in response to risperidone monotherapy in young children with nonpsychotic
Burcu Ersoz Alan1, S Ebru Cengel Kultur2
1Child and Adolescent Psychiatry Clinic, Dr. Sami Ulus Women and Children's Health and Diseases Training and Research Hospital, Telsizler/Altindag, Ankara, 06080, Turkey.
Background:
This study investigates changes in metabolic parameters in prepubertal children after 14-16 weeks of treatment with low-dose risperidone.
Method:
Thirty-one children (mean age 5.46 ± 1.98 years) were treated with risperidone (0.25-1 mg/day; 0.01-0.07 mg/kg/day). Patients were excluded if they were using any medication other than risperidone or were diagnosed with any medical problem in addition to a non-psychotic disorder.
Results:
Weight (Δ: 2.51 ± 1.94 kg), height (Δ: 0.03 ± 0.04 cm), BMI (Δ: 0.82 ± 1.4), BMI percentile (Δ: 9.72 ± 16.40), BMI z-score (Δ: 0.33 ± 1.03), triglyceride (Δ: 1.50 ± 23.97 mg/dl), very low density lipoprotein (Δ: 2.99 ± 4.76 mg/dl), insulin (Δ: 3.07 ± 3.38 mIU/ml), and leptin (Δ: 3.02 ± 4.69 ng/ml) were significantly increased (p < .05).
Conclusion:
The metabolic side effects of risperidone must be carefully monitored in prepubertal children.
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