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Updated: Dec 14, 2025

Direct Bioprinting of 3D Multicellular Breast Spheroids onto Endothelial Networks
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Improving Bioprinted Volumetric Tumor Microenvironments In Vitro.

Jun Li1, Carolina Parra-Cantu1, Zongyi Wang1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Trends in Cancer
|July 19, 2020
PubMed
Summary

Advanced bioprinting technologies create sophisticated 3D cancer models that better mimic the tumor microenvironment (TME). These biomimetic models are crucial for developing more effective cancer treatments and overcoming current therapeutic challenges.

Keywords:
3D modelsbioprintingcancertumor microenvironmenttumor on a chip

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Cancer Research and Therapeutics
  • 3D Bioprinting and Tissue Engineering

Background:

  • Despite significant advances in cancer research and drug development, curing most cancers remains a major challenge.
  • Existing preclinical cancer models often fail to accurately replicate the complex tumor microenvironment (TME).

Purpose of the Study:

  • To introduce recent advancements in bioprinting technologies for creating in vitro cancer models.
  • To highlight the applications of these advanced bioprinting techniques in cancer research.
  • To discuss the potential of 3D models and dynamic culture techniques in emulating the volumetric TME.

Main Methods:

  • Review and synthesis of current bioprinting technologies applicable to cancer modeling.
  • Integration of dynamic culture techniques with 3D bioprinting for enhanced biomimicry.
  • Focus on creating in vitro models that replicate the volumetric tumor microenvironment.

Main Results:

  • Bioprinting enables the development of sophisticated 3D cancer models.
  • These models show great potential in accurately emulating the complex tumor microenvironment (TME).
  • Dynamic culture techniques further enhance the biomimetic capabilities of these models.

Conclusions:

  • Bioprinting offers a promising avenue for developing more biomimetic and sophisticated preclinical cancer models.
  • These advanced models are essential for improving our understanding of cancer pathology and developing effective treatments.
  • Further research is needed to address current challenges in bioprinting strategies for faithful cancer modeling.