Neuro-fuzzy patch-wise R-CNN for multiple sclerosis segmentation

The segmentation of the lesion plays a core role in diagnosis and monitoring of multiple sclerosis (MS). Magnetic resonance imaging (MRI) is the most frequent image modality used to evaluate such lesions. Because of the massive amount of data, manual segmentation cannot be achieved within a sensible time that restricts the usage of accurate quantitative measurement in clinical practice. Therefore, the need for effective automated segmentation techniques is critical. However, a large spatial variability between the structure of brain lesions makes it more challenging. Recently, convolutional neural network (CNN), in particular, the region-based CNN (R-CNN), have attained tremendous progress within the field of object recognition because of its ability to learn and represent features. CNN has proven a last-breaking performance in various fields, such as object recognition, and has also gained more attention in brain imaging, especially in tissue and brain segmentation. In this paper, an automated technique for MS lesion segmentation is proposed, which is built on a 3D patch-wise R-CNN. The proposed system includes two stages: first, segmenting MS lesions in T2-w and FLAIR sequences using R-CNN, then an adaptive neuro-fuzzy inference system (ANFIS) is applied to fuse the results of the two modalities. To evaluate the performance of the proposed method, the public MICCAI2008 MS challenge dataset is employed to segment MS lesions. The experimental results show competitive results of the proposed method compared with the state-of-the-art MS lesion segmentation methods with an average total score of 83.25 and an average sensitivity of 61.8% on the MICCAI2008 testing set. Graphical Abstract The proposed system overview. First, the input of two modalities FLAIR and T2 are pre-processed to remove the skull and correct the bias field. Then 3D patches for lesion and non-lesion tissues are extracted and fed to R-CNN. Each R-CNN produces a probability map of the segmentation result that provides to ANFIS to fuse the results and obtain the final MS lesion segmentation. The MS lesions are shown on a pre-processed FLAIR image.