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Its written all over your face: The molecular and physiological consequences of aging skin

W E Lowry1

  • 1Department of Molecular Cell and Developmental Biology, UCLA, 621 Charles Young Drive South, Los Angeles, CA, 90095, United States; Division of Dermatology, David Geffen School of Medicine, UCLA, 621 Charles Young Drive South, Los Angeles, CA, 90095, United States; Molecular Biology Institute, UCLA, 621 Charles Young Drive South, Los Angeles, CA, 90095, United States; Broad Center for Regenerative Medicine, UCLA, 621 Charles Young Drive South, Los Angeles, CA, 90095, United States; Jonsson Comprehensive Cancer Center, UCLA, 621 Charles Young Drive South, Los Angeles, CA, 90095, United States.

Mechanisms of Ageing and Development
|July 19, 2020
PubMed

Insights

Skin aging, marked by wrinkles and hair changes, shares molecular causes with other tissues. Recent advances reveal key triggers and molecular underpinnings of skin aging, paving the way for future research.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Gerontology

Background:

  • Skin aging presents visible signs like wrinkles, hair graying, and age spots.
  • These changes reflect underlying physiological aging processes also seen in other tissues.
  • Decades of research have explored skin aging, with recent work uncovering fundamental molecular and physiological causes.

Purpose of the Study:

  • To summarize recent advancements in understanding the molecular and physiological causes of skin aging.
  • To highlight technological innovations enabling the detection and quantification of aging triggers in the skin.
  • To speculate on future research directions in the field of skin aging.

Main Methods:

  • Review of recent scientific literature on skin aging.
  • Analysis of technological advancements in detecting aging indicators.
  • Examination of molecular methods for determining the etiology of aging phenotypes.

Main Results:

  • Recent studies have illuminated fundamental molecular and physiological drivers of skin aging.
  • Technological progress allows for precise detection and quantification of aging triggers.
  • Molecular techniques are increasingly identifying the causes behind visible aging features.

Conclusions:

  • Understanding skin aging has significantly advanced due to molecular and technological breakthroughs.
  • Future research will likely focus on further elucidating molecular mechanisms and developing targeted interventions.
  • The study of skin aging provides insights applicable to aging processes in other tissues.
Keywords:
AgingDNA damageMetabolismSkinStem cells

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