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Coagulopathy in COVID-19: Focus on vascular thrombotic events

Wei Shi1, Jiagao Lv1, Li Lin1

  • 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

Journal of Molecular and Cellular Cardiology
|July 19, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) can cause coagulopathy, leading to severe complications and increased thrombosis risk. Understanding these mechanisms is crucial for developing effective COVID-19 treatments.

Area of Science:

  • * Infectious Diseases
  • * Hematology
  • * Critical Care Medicine

Background:

  • * Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, presents as pneumonia with diverse manifestations and high transmissibility, posing a global health challenge.
  • * Severe COVID-19 cases are associated with significant mortality, often linked to complications including coagulopathy.
  • * Coagulopathy is a prominent feature in COVID-19, characterized by severe coagulation dysfunction that correlates with poor prognosis.

Purpose of the Study:

  • * To review the clinical features of coagulation abnormalities in COVID-19 patients.
  • * To discuss the increased vascular thrombotic risk associated with COVID-19 coagulopathy.
  • * To explore potential mechanisms and emerging therapeutic strategies for managing hypercoagulability in COVID-19.

Main Methods:

  • * Literature review of current reports on COVID-19 and coagulopathy.
  • * Analysis of clinical features and thrombotic risks.
  • * Discussion of underlying pathomechanisms and therapeutic interventions.

Main Results:

  • * COVID-19 is frequently associated with coagulopathy, increasing the risk of thrombosis and vascular events.
  • * Potential mechanisms include inflammatory storm, endothelial injury, and renin-angiotensin system (RAS) dysregulation.
  • * Hypercoagulability in COVID-19 necessitates urgent development of effective interventions.

Conclusions:

  • * Coagulopathy is a critical factor in severe COVID-19, contributing to poor outcomes and thrombotic events.
  • * Understanding the mechanisms of COVID-19-associated coagulopathy is essential for guiding treatment.
  • * There is an urgent need for effective therapeutic strategies to address hypercoagulability in COVID-19 patients.

Keywords:
COVID-19HypercoagulabilitySARS-CoV-2Thrombosis

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