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Circulating endocannabinoid concentrations in grieving adults.

Elisabeth J Harfmann1, Timothy L McAuliffe2, Eric R Larson1

  • 1Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, Wisconsin, 53226, USA; Clement J. Zablocki Veterans Affairs Medical Center, 5000 W. National Ave, Milwaukee, Wisconsin, 53295, USA.

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Summary
This summary is machine-generated.

Grief alters the endocannabinoid signaling (ECS) system, with elevated AEA levels found in bereaved individuals. These changes may serve as biomarkers for prolonged grief disorder.

Keywords:
BereavementEndocannabinoid signaling systemEndocannabinoidsGriefOlder adultsProlonged grief disorder

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Area of Science:

  • Neurobiology
  • Psychiatry
  • Endocrinology

Background:

  • Bereavement is a significant stressor in the elderly, with varied symptom responses.
  • The neurobiological underpinnings of grief symptom variance remain poorly understood.
  • The stress-responsive endocannabinoid signaling (ECS) system is implicated in psychopathology.

Purpose of the Study:

  • To investigate if the ECS is abnormal in grief.
  • To use circulating endocannabinoid (eCB) concentrations as biomarkers of central ECS function.
  • To examine associations between eCBs and grief symptom variance.

Main Methods:

  • Studied a sample of grieving adults (n=44) and healthy comparisons (HC, n=17) within 13 months of bereavement.
  • Assessed grief, depression, and anxiety symptoms using validated scales.
  • Quantified serum concentrations of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) using mass spectrometry.

Main Results:

  • Grievers exhibited significantly elevated serum AEA compared to HC participants.
  • Serum 2-AG concentrations were similar between grievers and HC participants.
  • In grievers, elevated AEA was positively associated with depressive and anxiety symptoms in those with lower grief severity.

Conclusions:

  • Bereavement is associated with elevated circulating eCB concentrations.
  • The ECS response to grief varies with symptom severity.
  • Circulating eCB levels show potential as biomarkers for prolonged grief disorder.