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Multi-Modal Home Sleep Monitoring in Older Adults

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Published on: January 26, 2019

Anaesthesia-dependent oscillatory EEG features in the super-elderly.

K Hayashi¹, K Indo², T Sawa³

¹Department of Anesthesiology, Kyoto Chubu Medical Center, Yagi, Ueno 25, Nantan City, Kyoto, Japan; Medical Education and Research Center, Meiji University of Integrative Medicine, Kyoto, Japan.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|July 19, 2020

Summary

In super-elderly patients, electroencephalogram (EEG) δ-θ bicoherence increases with sevoflurane anesthesia, unlike α activity. This finding suggests δ-θ bicoherence may aid anesthesia monitoring in this population.

Keywords:

Ageing Bicoherence Geriatric assessment Neurophysiological monitoring Quadratic phase coupling α wave

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Area of Science:

Neuroscience
Anesthesiology
Gerontology

Background:

Electroencephalograms (EEGs) change with age, but their response to anesthesia in the very old is not well understood.
Previous studies have not detailed anesthesia-dependent oscillatory features or EEG reactivity in super-elderly patients.

Purpose of the Study:

To investigate age-related differences in EEG oscillatory features during sevoflurane anesthesia.
To examine anesthesia-dependent changes in EEG bicoherence and power spectrum in super-elderly versus young adult patients.

Main Methods:

Compared frontal EEG oscillatory features (bicoherence, power spectrum in α and δ-θ bands) in 20 super-elderly (87.1 years) and 20 young adult patients.
Analyzed EEG at three sevoflurane anesthesia levels (0.3, 0.7, 1.4 MAC) using the Friedman test.

Main Results:

Super-elderly patients showed anesthesia-dependent increases in δ-θ bicoherence (p=0.000), while α bicoherence remained unchanged (p=0.142).
Young adults exhibited anesthesia-dependent changes in both δ-θ and α bicoherence, contrasting with the super-elderly group.

Conclusions:

In the super-elderly, δ-θ bicoherence of EEG demonstrates anesthesia-dependent changes, whereas α activity is minimal regardless of anesthesia level.
Quantification of δ-θ bicoherence is proposed as a potential method for anesthesia monitoring in super-elderly individuals.