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MicroRNAs and ventricular remodeling in aortic stenosis

João Santos-Faria1, Cristina Gavina2, Patrícia Rodrigues3

  • 1Faculty of Medicine, University of Porto, Portugal.

Revista Portuguesa De Cardiologia
|July 20, 2020
PubMed
Abstract

Insights

MicroRNAs like miR-101-3p and miR-4268 are linked to left ventricular hypertrophy in aortic stenosis. They may predict reverse remodeling after aortic valve replacement, offering new therapeutic targets.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Aortic stenosis (AS) causes myocardial hypertrophy and fibrosis through various mechanisms.
  • MicroRNAs (miRNAs) are key post-transcriptional regulators of these cardiac remodeling processes.
  • Understanding miRNA expression in AS is crucial for identifying therapeutic targets.

Purpose of the Study:

  • To investigate the association between myocardial miRNA expression and left ventricular (LV) hypertrophy in patients with AS.
  • To explore the correlation between miRNA levels, LV remodeling, and plasma biomarkers of extracellular matrix turnover.
  • To assess the predictive value of specific miRNAs for reverse remodeling post-aortic valve replacement.

Main Methods:

  • Myocardial biopsies were obtained from 11 patients with severe AS undergoing aortic valve replacement.
  • Echocardiography and plasma biomarker quantification were performed.
  • MicroRNA expression was analyzed and compared to 5 explanted control hearts.

Main Results:

  • Overexpression of microRNA-101-3p correlated with higher preoperative valvuloarterial impedance and LV mass regression post-surgery.
  • Upregulation of miR-4268 and downregulation of microRNA-125-5p were associated with increased LV mass.
  • MicroRNA-4268 positively correlated with LV mass regression and higher plasma angiotensin II receptor levels.

Conclusions:

  • MicroRNA-101-3p and microRNA-4268 show potential roles in modulating the hypertrophic response to AS via the renin-angiotensin-aldosterone system.
  • These miRNAs may serve as predictors of reverse remodeling after aortic valve replacement.
  • Findings suggest novel therapeutic strategies targeting the renin-angiotensin-aldosterone system in hypertrophic hearts.
Keywords:
Aortic stenosisEstenose aórticaExtracellular matrixHipertrofiaHypertrophyMatriz extracelularMicroRNARenin-angiotensin-aldosterone systemSistema RAA

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