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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
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Regulated Cell Death in Pulpitis.

Minchun Huang1, Chaoning Zhan1, Xiaojun Yang1

  • 1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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|July 20, 2020
PubMed
Summary
This summary is machine-generated.

Regulated cell death (RCD) pathways, including pyroptosis and NETosis, contribute to pulpitis inflammation. Understanding RCD

Keywords:
ApoptosisNETosispulpitispyroptosisregulated cell death

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Area of Science:

  • Cell Biology
  • Immunology
  • Oral Pathology

Background:

  • Regulated cell death (RCD) encompasses various cell death modes crucial for development and pathogen defense.
  • Certain RCD pathways, like pyroptosis and NETosis, can trigger inflammation by releasing damage-associated molecular patterns.
  • Pulpitis, a common oral inflammatory disease, involves RCD, with its severity linked to specific cell death patterns.

Purpose of the Study:

  • To review the role of regulated cell death in pulpitis progression.
  • To identify molecular switch nodes that mediate crosstalk between different RCD pathways.
  • To explore how understanding RCD mechanisms can improve pulpal vitality preservation.

Main Methods:

  • Literature review focusing on regulated cell death (RCD) pathways.
  • Analysis of RCD involvement in pulpitis pathogenesis.
  • Identification of molecular crosstalk points between cell death pathways.

Main Results:

  • RCD, including apoptosis, pyroptosis, and NETosis, plays a significant role in pulpitis.
  • Mixed RCD patterns can indicate the severity of pulpal inflammation.
  • Specific molecular switch nodes connect different RCD pathways, influencing cell-fate decisions.

Conclusions:

  • Understanding RCD crosstalk in pulpitis is crucial for elucidating disease mechanisms.
  • Targeting molecular switch nodes may offer novel therapeutic strategies for pulpitis.
  • Insights into RCD can lead to better methods for preserving pulpal health and integrity.