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Updated: Dec 14, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

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Editorial: Mental Health in Pregnancy and Child Development: Implications for Mental Health Service Delivery

Allison G Dempsey1, Sage N Saxton2

  • 1University of Colorado School of Medicine, Aurora.

Journal of the American Academy of Child and Adolescent Psychiatry
|July 20, 2020
PubMed

Insights

Perinatal mood and anxiety disorders (PMADs) impact child development. Maternal stress during pregnancy can lead to adverse emotional, behavioral, and brain development outcomes in children.

Area of Science:

  • Perinatal mental health
  • Developmental neuroscience
  • Maternal-child health

Background:

  • Perinatal mood and anxiety disorders (PMADs) are common and require identification in obstetric and pediatric care.
  • Maternal prenatal adversity, including stress and depression, is linked to negative child outcomes.
  • These outcomes include altered emotional/behavioral functioning and brain development in offspring.

Discussion:

  • Potential mechanisms involve fetal ontogenetic vulnerabilities due to maternal PMADs.
  • Disruption of early parent-child bonding is another key pathway.
  • Understanding these links is crucial for early intervention.

Key Insights:

  • Maternal mental health during pregnancy significantly affects child development.
  • Prenatal adversity can manifest as structural brain changes in children.
  • Early parent-child relationship quality is influenced by maternal PMADs.

Outlook:

  • Integrating PMAD screening into primary care is essential.
  • Further research into neurodevelopmental impacts of maternal mental health is needed.
  • Developing targeted interventions can mitigate adverse child outcomes.

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