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COVID-19-associated coagulopathy

Massimo Franchini1,2, Giuseppe Marano1, Mario Cruciani1,3

  • 1Italian National Blood Centre, Rome, Italy.

Diagnosis (Berlin, Germany)
|July 20, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) causes a prothrombotic state due to links between inflammation and clotting. Monitoring coagulation in severe COVID-19 patients is crucial for managing thrombotic risk and guiding treatment.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pathophysiology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a systemic illness associated with a prothrombotic state.
  • The precise molecular mechanisms linking inflammation and hemostasis in COVID-19 coagulopathy remain under investigation.

Purpose of the Study:

  • To review the current understanding of COVID-19-associated coagulopathy.
  • To summarize its pathogenesis, epidemiology, clinical and laboratory features, and management strategies.

Main Methods:

  • This is a review article.
  • It synthesizes existing research on COVID-19 and coagulation.

Main Results:

  • COVID-19 induces a hypercoagulable state, increasing thrombotic risk in patients.
  • Laboratory monitoring is essential for identifying at-risk individuals and optimizing thromboprophylaxis.

Conclusions:

  • Understanding COVID-19 coagulopathy is vital for clinical management.
  • Further research into the pathogenesis and effective treatment of this complication is warranted.

Keywords:
COVID-19SARS-CoV-2anticoagulant therapyprophylaxisthromboembolismthrombosis

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