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Epilepsy in patients with insulin-dependent diabetes and relation to glutamic acid decarboxylase 65

Adel A Mahmoud1, Tayseer Abdelmagid, Mohammed AlGhofely

  • 1Department of Pediatric Neurology, National Neuroscience Institute, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)
|July 20, 2020
PubMed

Insights

Pediatric epilepsy is significantly associated with Insulin-dependent Diabetes (IDDM) in children. This study confirms a link between epilepsy in diabetic children and positive GAD65 antibodies, highlighting a crucial connection in pediatric care.

Area of Science:

  • Pediatric Endocrinology
  • Neurology
  • Immunology

Background:

  • Insulin-dependent Diabetes (IDDM) is a chronic condition affecting children.
  • Epilepsy is a neurological disorder characterized by recurrent seizures.
  • The co-occurrence of IDDM and epilepsy in pediatric populations warrants further investigation.

Purpose of the Study:

  • To determine if the association of epilepsy in pediatric patients with IDDM is higher than in the general pediatric population.
  • To investigate the relationship between epilepsy in diabetic children and the presence of anti-GAD65 antibodies.

Main Methods:

  • A cohort study of 305 pediatric patients (under 15 years) with IDDM was conducted.
  • Data on seizure disorder history were collected via questionnaires from caregivers.
  • Retrospective review of 214 patient files assessed anti-GAD65 antibody positivity.

Main Results:

  • A significant relationship was found between epilepsy and IDDM in children.
  • The presence of epilepsy in children with IDDM was confirmed to be associated with positive GAD65 antibodies.

Conclusions:

  • The study supports a consistent relation between IDDM and epilepsy in children.
  • A link between childhood epilepsy in diabetic patients and positive GAD65 antibodies is established.
Abstract

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