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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Related Experiment Video

Updated: Dec 14, 2025

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity
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In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity

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Microgravity effects on frozen human sperm samples.

M Boada1, A Perez-Poch2, M Ballester3

  • 1Women's Health Dexeus, Department of Obstetrics, Gynaecology and Reproduction, Hospital Universitari Dexeus, Avinguda Carles III 71-75, 08028, Barcelona, Spain. monboa@dexeus.com.

Journal of Assisted Reproduction and Genetics
|July 20, 2020
PubMed
Summary
This summary is machine-generated.

Microgravity exposure did not significantly alter frozen human sperm quality. This finding supports the safe transport of sperm for potential space exploration and future extraterrestrial sperm banks.

Keywords:
ApoptosisDNA fragmentationMicrogravityMotilitySpermVitality

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Area of Science:

  • Space biology and reproductive medicine
  • Cryobiology and gamete preservation

Background:

  • Microgravity poses significant challenges to cellular and molecular structures.
  • Understanding its impact on human reproductive cells is crucial for space exploration.

Purpose of the Study:

  • To investigate the effects of microgravity (μg) exposure on human frozen sperm samples.
  • To assess the viability and integrity of cryopreserved spermatozoa under simulated space conditions.

Main Methods:

  • Sibling sperm samples from 15 healthy donors were cryopreserved using glycerol.
  • Samples were analyzed under microgravity conditions achieved via parabolic flights (CAP10B aircraft).
  • Key parameters including motility, vitality, morphology, and DNA fragmentation were compared to ground controls (1 g).

Main Results:

  • No significant differences were observed in sperm motility, progressive motility, vitality, or morphology between microgravity and ground conditions.
  • Sperm DNA fragmentation and apoptosis rates also showed no significant alterations after microgravity exposure.
  • Frozen sperm samples stored in nitrogen vapor cryoshippers remained stable post-microgravity exposure.

Conclusions:

  • Cryopreserved human sperm samples exhibit resilience to microgravity exposure during simulated spaceflight.
  • These findings suggest the feasibility of safely transporting human gametes for space missions.
  • Further research is warranted to explore the establishment of extraterrestrial human sperm banks.