Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

125
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
125

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of modifiable lifestyle factors on dementia subtypes and brain structural changes across KDIGO risk categories in the UK biobank.

Brain imaging and behavior·2026
Same author

Diagnostic Ultrasound-guided Focused Ultrasound-induced Noninvasive, Reversible Peripheral Nerve Blockade in an In Vivo Model of Acute Pain: A Proof-of-Concept Study.

Anesthesiology·2026
Same author

Association of Weight-Adjusted-Waist Index With Brain Health: A 16-Year Population-Based Longitudinal Cohort Study.

CNS neuroscience & therapeutics·2026
Same author

Low-substrate nitrogen drives functional succession toward a cooperative Candidatus Brocadia consortium in anammox systems.

Bioresource technology·2026
Same author

Associations of clinical obesity with arterial stiffness and cerebral small vessel disease: a population-based study.

Frontiers in endocrinology·2026
Same author

Luteolin ameliorates cigarette smoke-induced chronic obstructive pulmonary disease by modulating gut and lung microbiota and amino acid metabolism in C57Bl/6 mice.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same journal

Body composition's effect on the bone-vascular axis of osteoporosis discovered in AI-based CT analysis of COPD patients.

European radiology·2026
Same journal

ESR Essentials: pelvic floor imaging-practice recommendations by the European Society of Urogenital Radiology.

European radiology·2026
Same journal

STIR or T2-Dixon? A false dilemma in musculoskeletal MRI.

European radiology·2026
Same journal

ESR Essentials: uterine cancers-practice recommendations by the European Society of Urogenital Radiology.

European radiology·2026
Same journal

Adjunctive quantification for more reproducible amyloid PET interpretation.

European radiology·2026
Same journal

APEX-NET: automated pancreatic evaluation network using early non-contrast CT.

European radiology·2026
See all related articles

Related Experiment Video

Updated: Dec 14, 2025

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.5K

MR elastography frequency-dependent and independent parameters demonstrate accelerated decrease of brain stiffness in

Han Lv1,2, Mehmet Kurt3, Na Zeng4

  • 1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

European Radiology
|July 20, 2020
PubMed
Summary
This summary is machine-generated.

Brain mechanical properties change with age, with decreased stiffness accelerating in those over 60. This study analyzed brain tissue elasticity and viscosity across different age groups using magnetic resonance elastography.

Keywords:
BrainElasticityMagnetic resonance elastographyNeuroimaging

More Related Videos

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
10:10

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Published on: July 20, 2022

4.4K
Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry
11:19

Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry

Published on: September 6, 2016

12.8K

Related Experiment Videos

Last Updated: Dec 14, 2025

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.5K
Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
10:10

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Published on: July 20, 2022

4.4K
Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry
11:19

Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry

Published on: September 6, 2016

12.8K

Area of Science:

  • Neuroscience
  • Biophysics
  • Medical Imaging

Background:

  • Brain mechanical properties change with age.
  • Understanding these changes is crucial for diagnosing age-related neurological conditions.
  • Magnetic Resonance Elastography (MRE) offers a non-invasive method to assess brain tissue biomechanics.

Purpose of the Study:

  • To analyze age-related changes in the mechanical properties of various brain regions in healthy adults aged 26-76.
  • To investigate frequency-dependent and frequency-independent biomechanical parameters.
  • To identify potential biomarkers for brain aging.

Main Methods:

  • Utilized a multifrequency magnetic resonance elastography (MRE) protocol.
  • Assessed frequency-dependent parameters (storage modulus G', loss modulus G″) and frequency-independent parameters (μ₁, μ₂, η).
  • Analyzed data from 46 healthy subjects across different age groups.

Main Results:

  • Annual decrease rates for G' ranged from -0.32% to -0.36%, and for G″ from -0.43% to -0.55% in the cerebral parenchyma, cortical gray matter (GM), and white matter (WM).
  • Subcortical GM showed changes in G' from -0.18% to -0.23% and G″ of -0.43%.
  • Males showed decreased elasticity, while females showed decreased viscosity with age in some subcortical regions; significant decreases were observed in individuals over 60.

Conclusions:

  • Storage (G') and loss (G″) moduli at 60 Hz, along with the frequency-independent parameter μ₂, in the caudate, putamen, and thalamus, can characterize brain aging.
  • Brain stiffness reduction accelerates in elderly individuals over 60.
  • Viscoelastic properties change differently in males and females in subcortical regions.